U.S. - France Cooperative Research: Asymmetric Cyclizations of Chiral Ketals

小行星9314076 这个为期三年的奖项支持美国-法国有机合成化学合作研究。Jung，加州大学，洛杉矶，Alex Alexakis，皮埃尔和玛丽居里大学，巴黎，法国。 他们的研究目的是研究在各种环化反应中的同手性缩酮和缩胺的不对称诱导。 它们将决定这些化学过程在有机合成中的实用性，即这些环化反应是否进行得足够好，以便在光学纯形式的复杂天然产物的合成中普遍有用。 该项目利用了法国在手性缩酮和缩胺合成方面的专业知识。 这与美国集团在分子内环化反应方面的专业知识相辅相成。 这一建议将促进对有机合成和表征新技术的理解。 它也可以形成天然产物的设计合成的基础。

9314076 Jung This three-year award supports U.S.-France cooperative research in organic synthesis chemistry between Michael E. Jung, University of California, Los Angeles, and Alex Alexakis, Pierre and Marie Curie University, Paris, France. The objective of their research is to study asymmetric induction of homochiral ketals and aminals in various cyclization reactions. They will determine the utility of these chemical processes in organic synthesis, namely whether these cyclizations proceed well enough to be generally useful in the synthesis of complex natural products in optically pure form. This project takes advantage of French expertise in chiral ketals and aminals in synthesis. This is complemented by the U.S. group's expertise in intramolecular cyclization reactions. This proposal will advances understanding of new techniques for organic synthesis and characterization. It may also form the basis for designed synthesis of natural products.