U.S.-France Cooperative Research: Catalytic Antibody Models for Hemeproteins

小行星9314423 这个为期两年的奖项支持美国-法国勒内·笛卡尔大学的斯蒂芬·J·本科维奇和让-皮埃尔·马伊在生物化学方面的合作研究，巴黎，法国。 他们的研究目标是创造催化抗体，类似于血红素蛋白中发现的那些，具有诱导对适当半抗原的免疫反应的能力。 半抗原是一种不完整的抗原，本身不能引起抗体形成。 美国研究人员为这项合作带来了抗体诱导、筛选和催化剂选择方面的专业知识。 他将专注于抗体促进反应的机械特性，并产生抗体结构的计算机模型。 法国研究人员在卟啉半抗原的合成、表征和化学性质方面的专业知识对此进行了补充。 这项研究将促进这些催化抗体的发展，并加强对蛋白质对“血红素”（血红蛋白的铁成分）催化特性的影响的理解。 ***

9314423 Benkovic This two-year award supports U.S.-France cooperative research in biochemistry between Stephen J. Benkovic and Jean-Pierre Mahy of the University Rene Descartes, Paris, France. The objective of their research is to create catalytic antibodies, similar to those found in hemeproteins, with the ability to induce an immunological response to an appropriate hapten. A hapten is an antigen that is incomplete and cannot by itself cause antibody formation. The U.S. investigator brings to this collaboration expertise in antibody induction, screening and selection of catalysts. He will focus on the mechanistic characterization of antibody promoted reactions and produce a computer model of the antibody structure. This is complemented by the French investigator's expertise in the synthesis, characterization and chemical properties of porphyrin haptens. The research will advance the development of these catalytic antibodies and enhance understanding of the influence of proteins on the catalytic properties of "heme" - the iron component of hemoglobin. ***