U.S.-France Cooperative Research: Tissue Specific Transcriptional Regulation of the Human ApoA-II Gene

9314607赞尼斯这个为期三年的奖项支持波士顿大学的Vassilis Zannis和Hotel Dieu大学细胞生物系的Jean Chambaz在遗传学方面的美法合作研究。上帝饭店是位于巴黎的一家大医院。他们的研究目标是从小鼠中分离和表征ApoA-II（载脂蛋白）基因的组织特异性转录调节因子。载脂蛋白的调控是重要的，因为它们决定了细胞受体对脂蛋白的细胞识别和分解代谢。它们还在维持细胞胆固醇稳态和动脉粥样硬化的发病机制中发挥作用。这位美国研究者是一位生物化学家，他为这次合作带来了脂蛋白研究方面的专业知识，包括载脂蛋白的结构和功能以及基因调控。这与法国研究者在细胞生物学和基因表达方面的专业知识相辅相成。该项目还利用了上帝酒店（Hotel Dieu）的转基因小鼠设施，大部分试验将在那里进行。＊＊＊

9314607 Zannis This three-year award supports U.S.-France cooperative research in genetics between Vassilis Zannis of Boston University and Jean Chambaz of the Department of Cellular Biology, Hotel Dieu. The Hotel Dieu is a major hospital located in Paris. The objectives of their research are to isolate and characterize the tissue specific transcriptional regulators of the ApoA-II (apolipoprotein) gene from mice. The regulation of apolipoproteins is important since they determine the cellular recognition and catabolism of lipoproteins by cell receptors. They also play a role in the maintenance of cellular cholesterol homeostasis and in the pathogenesis of atherosclerosis. The U.S. investigator, who is a biochemist, brings to this collaboration expertise in lipoprotein research, including structure and function of the apolipoprotein and gene regulation. This is complemented by the French investigator's expertise in cell biology and gene expression. The project also takes advantage of a transgenic mouse facility at the Hotel Dieu where most of the testing will take place. ***