Request for Acquisition of Instrumentation for the Study of Macromolecular Interactions

要求配备研究大分子相互作用的设施所需的主要仪器。 这些中心围绕着贝克曼OPTIMA -XL -分析离心机。 为了补充这一设备，需要一台动态光散射仪，并对现有荧光仪器进行升级。该设备将用于确定大分子复合物内的蛋白质平衡距离、DNA蛋白质复合物、病毒颗粒和核酸的分子量和颗粒形状。 这样的设施不存在于科罗拉多大学系统内，并且是一组研究人员对其结构和机械研究的迫切需要。

Major instruments required to equip a facility for the study of macromolecular interaction are requested. These center around a Beckman OPTIMA -XL - a analytical centrifuge. To complement this equipment, a dynamic light scattering instrument and upgrades to existing fluorescence instrumentation are requested. This equipment will be used to determine protein equilibria distances within macromolecular complexes, molecular weights and particle shapes for DNA protein complexes, viral subassemblies and nucleic acids. Such a facility does not exist within the University of Colorado system and is severely needed by a group of investigator for their structural and mechanistic studies.