Syntheses of Mitomycin C and FR900482 Via Dialkylvinyl- sulfonium Salts

本研究的重点是天然产物的合成， 二烷基乙烯基锍盐作为试剂的用途的发展 用于制备构建丝裂霉素C的中间体 和FR900482。 教育计划的重点涉及发展 一个新的药物设计和机制的研究生课程， 让本科生参与到活跃的实验室体验中。 有了这个职业奖，合成有机计划是支持 莱斯利·希门尼斯博士的研究和教育计划 罗格斯大学的化学系。 希门尼斯教授会让她 研究工作的发展，短期有效的合成， 天然产物丝裂霉素C和FR 900482。 希门尼斯医生的重点 教育计划涉及一个新的研究生课程的发展， 药物设计和机制，以及涉及大学生在一个 积极的实验室经验。

The focus of this research is on natural product synthesis and relies on the development of the use of dialkylvinylsulfonium salts as reagents for the preparation of intermediates for the construction of mytomycin C and FR900482. The focus of the educational plan involves the development of a novel graduate course in drug design and mechanism as well as involving undergraduates in an active laboratory experience. With this CAREER award, the Synthetic Organic Program is supporting the research and educational plan of Dr. Leslie Jimenez of the Department of Chemistry at Rutgers University. Professor Jimenez will focus her research efforts on the development of short efficient syntheses of the natural products mitomycin C and FR900482. The focus of Dr. Jimenez' educational plan involves the development of a novel graduate course in drug design and mechanism as well as involving undergraduates in an active laboratory experience.