CAREER: Engineering the Behavior of Mammalian Cells Cultured on Elastomeric Substrata

[502648] DiMilla这个项目是研究细胞-生物材料相互作用的。本研究的内容包括：(1)聚硅氧烷的合成，其流变性能将系统地改变；(2)通过纤维连接蛋白吸附或生物活性肽的掺入进一步改变该介质；(3)测量黏附胶质母细胞瘤细胞在这些材料上的运动、形态和增殖；(4)建立了描述表面力学性能对细胞行为影响的数学模型。除了这项研究活动，研究者将通过开发一门新的课程，并最终出版一本关于细胞和组织系统工程分析的书来加强教育。＊＊＊

9502648 DiMilla This project is on research to study cell-biomaterial interactions. The elements of this research include: (1) the synthesis of polysiloxanes in which the rheological properties will be systematically varied; (2) the further alteration of this media by fibronectin adsorption, or the incorporation of biologically active peptides; (3) the measurement of the motility, morphology, and proliferation of adherent glioblastoma cells on these materials; and (4) the development of a mathematical model to describe the influence of surface mechanical properties on cell behavior. In addition to this research activity, the investigator will enhance education by developing a new course, and eventually a book, on the engineering analysis of cell and tissue systems. ***