Super-Resolution Nanothermometry on Live Cells

该项目旨在提供新的温度传感器，并推动纳米测温领域超越其光学衍射限制和当前的可靠性问题。该项目希望通过创建活细胞的超分辨率热图来打造一种研究细胞器新陈代谢和功能相互作用的新方法。预期成果包括关于稀土离子之间离子能量转移的新知识、创新的超分辨率成像纳米温度计、新的生物化学和细胞生物学协议以及光谱和显微镜仪器。在新技术中采用这些成果应该会在细胞生物学研究、生命科学、工程科学以及澳大利亚的成像和传感器行业带来显著的好处。

This project aims to deliver new temperature sensors and advance the field of nanothermometry beyond its optical diffraction limit and current reliability issues. The project expects to forge a new way to study organelle metabolism and functional interactions by creating a super-resolution heat map of living cells. Expected outcomes include new knowledge of ionic energy transfer among lanthanide ions, innovative super-resolution imaging nanothermometers, new biochemistry and cell biology protocols, and spectroscopy and microscopy instruments. The adoption of these outcomes in new technologies should provide significant benefits in cell biology research, life sciences, engineering sciences and Australia’s imaging and sensor industries.