New Radical Processes: Kinetics and Synthesis

本研究的重点是利用自由基反应作为关键合成步骤合成对映体纯分子。这是基于这样一种观察，即小的、看似活性的环体系可以转化为自由基，并被诱导进行环化，比重排更快。这形成了一种构建碳-碳键的新策略，并最终形成了更复杂的材料。这些快速自由基重排的动力学也将被研究。氧基羰基和氮基羰基自由基将是这些研究的重点。有了这个更新奖，合成有机项目支持耶鲁大学化学系的Fred E. Ziegler博士的研究。齐格勒教授将集中研究碳-碳键的形成，这是有机分子合成的一个基本过程，利用自由基反应提供对映体纯材料。这些研究将提供新的合成途径，可能适用于通过阴离子和阳离子方法无法达到的途径制备重要的抗生素

The focus of this research is the synthesis of enantiomerically pure molecules using free radical reactions as the key synthetic step. This is based on the observation that small, seemingly reactive ring systems can be converted into radicals and be induced to undergo cyclization faster than rearrangement. This forms a new strategy for the construction of carbon-carbon bonds, and ultimately, more complex materials. Kinetics of these rapid radical rearrangements will also be studied. Oxiranylcarbinyl and aziridinyl radicals will be the focus of these studies. With this renewal award, the Synthetic Organic Program is supporting the research of Dr. Fred E. Ziegler of the Department of Chemistry at Yale University. Professor Ziegler will focus his research on carbon-carbon- bond formation, a fundamental process in the synthesis of organic molecules, using free radical reactions to provide enantiomerically pure materials. These studies will provide new avenues of synthesis that may be applicable to the preparation of important antibiotics through pathways inaccessible by anionic and cationic methods