Asymmetric Catalysis in Supercritical Media

该奖项是在环境无害化学合成和加工项目中获得的，由环境保护局化学部和污染预防和毒物办公室资助。此外，该项目还包括与康涅狄格州里奇菲尔德的研究科学家、勃林格殷格翰公司实验室和洛斯阿拉莫斯国家实验室的合作。杜克大学化学系的Mark J. Burk将开发利用二氧化碳溶剂系统进行不对称催化反应的化学合成和加工技术。不对称氢化，氢转移还原和醛醇缩合将被研究。化学工业使用大量的有机和氯化溶剂，这些溶剂存在严重的处置或回收问题。本项目将探讨二氧化碳作为替代溶剂在精细化学品生产中的应用。不对称催化是一种为手性药物和农用化学品的合成提供对映纯中间体的高效途径的方法。在超临界二氧化碳中进行不对称催化，有效地结合了两者的优点，减少了制造过程中的化学物质释放。

This award is made in the Environmentally Benign Chemical Synthesis and Processing program and is funded by the Division of Chemistry and the Office of Pollution Prevention and Toxics of the Environmental Protection Agency. In addition, the project includes collaboration with research scientists at the Ridgefield, Connecticut, laboratories of Boehringer Ingelheim Corporation and Los Alamos National Laboratories. Mark J. Burk of the Chemistry Department, Duke University, will develop chemical synthesis and processing technologies using carbon-dioxide based solvent systems for asymmetric catalytic reactions. Asymmetric hydrogenations, hydrogen transfer reductions, and aldol condensations will be investigated. Chemical industry uses large volumes of organic and chlorinated solvents which present serious disposal or recycling problems. The utility of carbon dioxide as a replacement solvent for the manufacture of fine chemicals will be examined in this project. Asymmetric catalysis is a method that offers energy-efficient access to enantiometrically pure intermediates for the synthesis of chiral drugs and agrochemicals. Performing asymmetric catalysis in supercritical carbon dioxide effectively combines the advantages of both to reduce chemical release in manufacturing.