Biomimetic Oxidation Chemistry

有机动力学项目的这一资助支持犹他州大学辛西娅·伯罗斯教授的继续研究。 主要目标是对DNA和其他小分子进行位点特异性金属催化修饰的实验。 需要解决的基本问题是影响镍配合物对DNA烷基化的双氧因素的活化和镍催化氧化小分子的动力学参数。 氧化是化学中的一个基本反应，当应用于有机和生物分子时，它可能是有用的，也可能是有害的。 在某些情况下，它有助于降解和解毒，在其他情况下，它可以引发癌症。 因此，彻底了解这些类型的反应非常重要。 该提案解决了该领域的一个具体方面，其中镍促进DNA的氧化，DNA是生物系统的重要组成部分。

This grant from the Organic Dynamics Program supports the continuing research of Professor Cynthia Burrows at the University of Utah. Primary objectives are experiments on the site-specific metal catalyzed modification of DNA and other small molecules. Fundamental problems to be solved are the activation of dioxygen factors influencing the alkylation of DNA by nickel complexes and the dynamic parameters of nickel catalyzed oxidation of small molecules. Oxidation is a fundamental reaction in chemistry which when applied to organic and biological molecules can be useful as well as deleterious. It assists degradration and detoxification in some instances and it can initiate cancer in other conditions. Thus, a thorough understanding of these types of reactions is very important. This proposal addresses a specific aspect of the field wherein nickel facilitates the oxidation of DNA, a significant component of biological systems.