Carbanions and Physical Organic Chemistry

在有机动力学项目的资助下，加州大学伯克利分校的Streitwieser教授将继续他对极性有机金属试剂反应动力学的研究。通过实验和理论化学，对控制这些配合物聚集及其相对反应性的因素将有更透彻的了解。一个主要的问题仍然困扰研究人员在这一领域是试剂聚集与反应性的状态。这个建议解决了这个问题。由于这些试剂在有机合成中无处不在，因此科学家们对化学选择性和立体选择性方面的反应性的理解将对其使用产生重大影响。合成有机化学负责新方法和生理活性化合物的实际制备，在很大程度上依赖于特定试剂来实现某些有机转化。这些试剂有些是复杂的，有多种形式。由于确切的形式影响其反应效率，因此了解影响这些试剂的因素是很重要的。这项提议的努力将解决极性有机金属试剂方面的这些问题。

With funding from the Organic Dynamics Program, Professor Streitwieser at the University of California-Berkeley is to continue his studies on the reaction dynamics of polar organometallic reagents. Through experimental as well as theoretical chemistry, a more thorough understanding of the factors governing the aggregation of these complexes and their relative reactivities will be garnered. One of the major questions still confounding investigators in this area is the state of reagent aggregation versus reactivity. This proposal addresses this issue. Since these reagents are ubiquitous in organic synthesis, an understanding that allows scientists to predict the reactivity with regard to chemoselectivity and stereoselectivity would have significant impact on the use. Synthetic organic chemistry which is responsible for new methodologies and actual preparations of physiologically active compounds relies heavily on specific reagents to effect certain organic transformations. Some of these reagents are complex and have a variety of forms. Since the exact form affects the efficiency of its reactivity, it is important to understand the factors influencing these reagents. This proposed effort will address these issues with regard to polar organometallic reagents.