High Field NMR Study of Antitumor Active Platinum Complexes with Trans. Geometry

本研究以铂类抗肿瘤化合物中反式构型的活化为研究重点，首先研究了反式-PtCl2(NH3)(喹啉)与不同碱基和核苷酸的反应。将制备铂(IV)类似物，并将使用二维和多核核磁共振仔细比较铂(II)和铂(IV)与寡核苷酸的反应活性。Roat博士还将在荷兰莱顿大学的Gorlaeus实验室进行夏季研究，以继续与Jane Rudijik进行研究合作。陪同她的还有弗吉尼亚联邦大学的一名研究生和华盛顿学院的一名本科生。互动活动包括：教授本科生/研究生水平的生物无机化学课程；为本科生组织研讨会，面向女性和少数族裔，致力于收集本科和研究生研究以及学术奖学金和奖学金的竞争性申请；以及与荷兰莱顿大学的东道国和本国机构学生之间的暑期研究交流，Roat博士在那里有广泛的合作研究联系。

This research focuses on activation of the trans geometry in platinum antitumor complexes, first studying the reactions of trans- PtCl2(NH3)(quinoline) with various nucleobases and nucleotides. Platinum (IV) analogs will be prepared and a careful comparison of platinum (II) and platinum (IV) reactivity with oligonucleotides will be undertaken using two dimensional and multinuclear nuclear magnetic resonance. Dr. Roat will also spend a summer research period in the Netherlands at Leiden University's Gorlaeus laboratories to continue research collaboration with Jane Rudijik. She will be accompanied by a graduate student from Virginia Commonwealth University and an undergraduate from Washington College. Interactive activities include: teaching an undergraduate/graduate level course in Bioinorganic Chemistry; organizing seminars for undergraduates, targeting women and minorities, devoted to putting together competitive applications for undergraduate and graduate research and academic scholarships and fellowships; and implementing a summer research exchange between host and home institution students with Leiden University, the Netherlands where Dr. Roat has extensive collaborative research contacts.