Regulation of epidermal morphogenesis and barrier function by intercellular junctions (A01)
Regulation of epidermal morphogenesis and barrier function by intercellular junctions (A01)
细胞间连接对表皮形态发生和屏障功能的调节 (A01)
批准号：
109137064
负责人：
金额：
$0.0万
依托单位国家：
德国
项目类别：
Collaborative Research Centres
财政年份：
2009
资助国家：
德国
项目状态：
已结题
起止时间：
2008-12-31 至 2019-12-31
中文摘要
翻译
我们已经证明，经典钙粘蛋白通过调节细胞间连接、细胞骨架和激酶信号传导对表皮屏障的形成和结构完整性至关重要。本项目的总体目标是揭示细胞间连接协同调节组织结构、完整性和表皮屏障功能的形成、维持和恢复的机制。
英文摘要
We have demonstrated that classical cadherins through regulation of intercellular junctions, the cytoskeleton and kinase signaling are crucial for the formation and structural integrity of the epidermal barrier. The overall goal of this project is to unravel the mechanisms by which intercellular junctions cooperate to regulate the formation, maintenance and restoration of tissue architecture, integrity and epidermal barrier function.
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