U.S.-France Cooperative Research: Kinetic Studies of the Folding of Thioredoxin By Fragment Complementation

这个为期三年的奖项支持美国和法国在分子生物学方面的合作研究，参与者包括纽约城市大学城市学院的Maria Tasayco以及法国巴黎巴斯德研究所的Michel Godlberg和Alain Chaffotte。他们的研究目的是研究蛋白质折叠问题。具体来说，他们将研究大肠杆菌硫氧还蛋白片段重建大分子原始结构的途径。他们提出通过对硫氧还蛋白功能的研究来阐明其结构和蛋白质折叠途径。美国研究者为这次合作带来了结构研究和方法方面的专业知识。法国研究人员在蛋白质折叠动力学研究方面的专业知识补充了这一点。该研究将促进我们对生物大分子结构与功能关系的认识。

This three-year award, which supports U.S.-France cooperative research in molecular biology, involves Maria Tasayco of the City University of New York's City College and Michel Godlberg and Alain Chaffotte of the Institut Pasteur in Paris, France. The objective of their research is to study the protein folding problem. Specifically, they will investigate pathways by which fragments of E. Coli thioredoxin reconstitute the original structure of macromolecules. Through the study of the function of thioredoxin, they propose to elucidate structure and the protein folding pathway. The U.S. investigator brings to this collaboration expertise in structural studies and approaches. This is complemented by the French investigators' expertise in kinetic studies of protein folding. The research will advance our understanding of the relationship between structure and function in biological macromolecules.