Renovation of Laboratory Space in the Chemistry Department for Biomolecular Research

分子水平的科学和技术进步为解决生物学和化学之间的关键问题提供了引人注目的新方法。 这些进展很可能重新定义现有领域之间的界限，传统学科之间的思想交叉将允许在生物技术和先进分子材料方面发展新的成功合作。 分子生物学方法在加州大学滨江分校（UCR）化学系的几个研究实验室中使用。 然而，教师分散在皮尔斯大厅内的许多地方，其中化学空间建于1965年。 该建筑缺乏进行以下领域教师研究所需的某些核心设施：无机化学、生物材料化学、受体-配体结合化学、合成有机化学和核酸化学。 NSF和UCR之间的伙伴关系将建立，以开发所需的研究基础设施，为跨越化学传统界限的合作努力的扩展和发展提供物理重点。 改善皮尔斯大厅的研究基础设施将涉及三楼21个研究实验室空间的翻新。 装修包括：石棉消除，拆除不符合规范的通风橱、水槽和钳工，升级公用事业系统，增加电力、蒸汽和工业热水，修复暖通空调、煤气、真空和管道，安装橱柜、通风橱和橱柜。 将建立共同使用的核心设施，包括冷藏室、离心机室、多用途仪器室、3级重组DNA设施和热实验室。 这个项目，补充了以前的ARI冷水项目在皮尔斯大厅，将直接提高五个高级人员，八个博士后，20名研究生和11名本科生的研究前景。 拥有现代化的设施将改善研究培训的机会，为学生在化学生物学接口的研究兴趣。 由于该大学的少数民族学生比例最高，女性占UCR学生总数的52%以上，因此该项目将对这些个人群体进入物理科学的招聘产生影响，因为这两个群体的人数都严重不足。

Scientific and technological advances at the molecular level are providing dramatic new approaches to address critical problems at the interface between biology and chemistry. These advances may well redefine current boundaries between existing fields, and cross fertilization of ideas across traditional disciplines will allow the development of new successful collaborations in biotechnology and advanced molecular materials. Molecular biological approaches are used in several research laboratories in the chemistry department at the University of California - Riverside (UCR). However, faculty are dispersed in many locations within Pierce Hall, in which space for chemistry was constructed in 1965. The building lacks certain core facilities necessary for the conduction of faculty research in the following areas: inorganic chemistry, chemistry of biomaterials, receptor-ligand binding chemistry, synthetic organic chemistry, and nucleic acid chemistry. A partnership between the NSF and UCR will be established to develop the required research infrastructure to provide a physical focus for extension and development of collaborative efforts across tradition boundaries in chemistry. Improving the research infrastructure in Pierce Hall will involve the renovation of 21 research laboratory spaces on the third floor. Renovations include: asbestos abatement, removal of non-code compliant fume hood, sinks, and benchwork, upgrade of utility systems to include additional power, steam and industrial hot water, reconditioning of HVAC, gas, vacuum and plumbing lines, and the installation of casework, fume hoods, and cabinets. Joint-use core facilities including cold rooms, a centrifuge room, multipurpose instrumentation rooms, a Level 3 recombinant DNA facility and a hot lab will be created. This project, complementing a previous ARI Chilled Water Project in Pierce Hall, will directly enhance the research prospects for five senior personnel, eight postdocs, twenty graduate students and eleven undergraduate students. Having modern facilities will improve research training opportunities for students with research interests at the Chemistry-Biology interface. Since the university has the largest percentage of minority students of any UC campus, and women comprise over 52% of the UCR student body, this project will have an impact on the recruitment of these groups of individuals into the physical sciences where both are seriously underrepresented.