U.S.-France Cooperative Research: Probing the Dynamics of Ribozymes by 13C NMR Relaxation

这项为期三年的奖项支持科罗拉多大学的Arthur Pardi和法国国家科学研究中心结构生物学研究所的Dominique Marion在分子生物化学方面的美法合作研究。该项目还为一名博士后研究员和研究生提供旅行支持。这项研究的目的是应用法国实验室开发的核磁共振弛豫技术来探索蛋白质在溶液中的动力学。该项目利用了法国的专业知识，将促进对核酶对RNA底物的位点特异性切割中动力学作用的理解。

This three-year award supports U.S.-France cooperative research in molecular biochemistry between Arthur Pardi of the University of Colorado and Dominique Marion of the Structural Biology Institute at the French National Center for Scientific Research. The project also provides travel support for a postdoctoral researcher and graduate student. The objective of the research is to probe the dynamics of proteins in solutions by applying NMR relaxation techniques developed by the French laboratory. This project takes advantage of French expertise and will advance understanding of the role of dynamics in site-specific cleavage of RNA substrates by ribozymes.