RUI: Swimming in Rainbow Trout: Ontogeny and Muscle Function

9604140 Coughlin Fish为肌肉功能的研究提供了一个优雅的系统。鱼的不同肌肉纤维类型(慢、中、快)的位置和用途的不同，可以评估每种肌肉类型对运动的贡献。虹鲑鱼在稳定或持续的游泳(即只使用缓慢的有氧肌肉纤维的游泳)过程中，显示出许多有趣的肌肉功能特征。考夫林博士将探索游泳鲑鱼的身体弯曲和肌肉电激活的不同模式如何影响肌肉功能和运动。此外，通过比较鲑鱼不同的生活史阶段，如PARR和SMOLT阶段，PI将检查身体形状和肌肉动力学的发育变化如何影响游泳性能。最后，通过激素控制，彩虹鲑鱼的发育将被控制，以比较不同生活史阶段的游泳情况，并控制每个阶段的自然大小差异。对鱼类游动的研究增加了对所有脊椎动物肌肉功能的了解。虽然这项研究将重点放在游动鱼类的有氧肌肉功能上，但它对我们理解其他系统中的有氧肌肉功能也有意义，特别是其他周期性活动的肌肉，如鸟类的飞行肌肉和哺乳动物四肢的发电肌。

9604140 Coughlin Fish provide an elegant system for the study of muscle function. Variations in the location and usage of the different muscle fiber types (slow, intermediate and fast) of fish permit evaluation of how each muscle type contributes to locomotion. Rainbow trout, Oncorhynchus mykiss, show a number of interesting characteristics of muscle function during steady or sustained swimming (i.e. swimming that employs the slow, aerobic muscle fibers only). Dr. Coughlin will explore how distinct patterns of body curvature and electrical activation in the muscle of swimming trout affect muscle function and locomotion. Also, through comparison of the discrete life history stages observed in trout, such as the parr and smolt stages, the PI will examine how developmental changes in body shape and muscle kinetics effect swimming performance. Lastly, through hormone manipulation, rainbow trout development will be manipulated to allow comparisons of swimming at the different life history stages with control for natural differences in size at each stage. The study of fish swimming increases the understanding of muscle function in all vertebrates. While this study will focus on aerobic muscle function in swimming fish, it has implications for our understanding of aerobic muscle function in other systems, especially other cyclically active muscle such as bird flight muscle and the power generating muscle of mammalian limbs.