SFB 858: Synergetic Effects in Chemistry - From Additivity towards Cooperativity

CRC 858以跨学科的方式将合作效应应用于化学系统的构建和激活，旨在将“合作”一词发展成为一种普遍原则，特别是在化学科学中。协同效应将使化学反应达到更高的效率，并理解如何以良好定义的方式构建化学结构。这些目标在两个层面上进行了探索：在分子水平上，研究了较小的确定化合物的协同效应，这些化合物可以通过分析技术和计算方法很好地表征。在系统层面，复杂的结构进行了研究，包括表面决定的过程，涵盖合成无机材料以及生物系统。所有的研究领域都被理论化学联系在一起。在所研究的所有系统中，单个化学实体施加的合作相互作用导致的结果与所有单个实体的影响总和不同。CRC 858中的一个热门话题是用于开发新型化学反应的受挫Lewis酸/碱对（FLPs）化学。在双金属和多金属体系中，研究了有机金属化合物中相互作用金属的协同效应，包括已建立的配体结构和非传统的配体，如DNA。这一领域现在已经扩展到纳米团簇的制备及其在催化中的应用，因此对多相催化领域做出了重要的贡献。在开创性的贡献中，表面被用作（预）组织的平台和传导二维化学反应的介质，其中表面作为单个分子离散排列的指导因素和成键反应的催化剂协同作用。磁性是由单个原子或分子的相互作用产生的。CRC通过构建基于理论预测的合成和分析的有机多旋体体系来实现这一目标。协同性是各种生物系统功能的关键问题，例如当调节动态生物膜的表面时。通过理论和实验相结合的方法，CRC研究了弱合作相互作用作为蛋白质和蛋白质-碳水化合物识别的驱动力。此外，通过化学偶联蛋白质和安装合成探针，研究了蛋白质与蛋白质和蛋白质与rna的相互作用。CRC 858包含了协同性的基本方面，这是一个在化学和物理中不断使用的术语。研究人员发展了一般概念，以促进对合作一词的普遍接受的看法。与它的参与机构一起，<s:1>国家科学技术大学与纳米技术中心（CeNTech）提供了一个理想的基础设施，跨学科研究化学协同效应。

The CRC 858 applies cooperative effects to the construction and activation of chemical systems in an interdisciplinary approach, aiming at evolving the term cooperativity into a general principle in particular for chemical sciences. Cooperative effects will allow steering chemical reactivity to a higher degree of efficiency and understanding how chemical structures can be constructed in a well-defined manner. These goals are explored at two levels: at the molecular level cooperative effects are investigated on smaller defined compounds which can be well characterized by analytical techniques and by computational methods. At the systemic level, complex structures are investigated, including surface determined processes, covering synthetic inorganic materials as well as bio systems. All research fields are linked by theoretical chemistry. In all systems studied cooperative interactions exerted by individual chemical entities lead to an outcome which is different from the sum of the impacts of all individual entities.One hot topic within the CRC 858 is the chemistry of frustrated Lewis acid / -base pairs (FLPs) for the development of novel chemical reactions. In bi- and multi metallic systems cooperative effects of interacting metals in organometallic compounds are studied, including established ligand structures and unconventional ligands like DNA. This area now is extended towards the preparation of nanoclusters and their application in catalysis, therefore important contributions to the field of heterogeneous catalysis have been made. In pioneering contributions surfaces are exploited as platforms for (pre)organisation and as mediators for the conduction of 2D chemical reactions, where the surface acts cooperatively as steering factor for the discrete arrangement of individual molecules and as catalyst for the bond forming reaction. Magnetism arises from cooperative interactions of individual atoms or molecules. CRC contributes to this by construction of organic polyspin systems, synthesized and analyzed based on theoretical predictions. Cooperativity is a key issue for function in various biological systems, e.g. when modulating the surface of dynamic biomembranes. With combined theoretical and experimental methods the CRC investigates weak cooperative interactions as driving forces for protein-protein and protein-carbohydrate recognition. Furthermore, protein-protein and protein-RNA interactions are studied by chemically conjugating proteins and by installing synthetic probes.The CRC 858 bundles fundamental aspects of cooperativity, a term that cumulatively is used in chemistry and physics. The researchers develop general concepts in order to contribute to a generally accepted perception of the term cooperativity. With its participating institutions the University of Münster offers together with the Center for Nanotechnology (CeNTech) an ideal infrastructure for interdisciplinary research on Synergistic Effects in Chemistry.