Field Enhanced Continuous Preparative Chiral Separation of Herbicide, Insecticide, and Fungicide Enantiomers for Reduced Environmental Burden

摘要该项目是一项计算和实验相结合的研究，旨在开发一种通用的田间增强的手性农药连续电泳分离方法。该过程是三维的，并将小的电泳迁移率差异放大为环空中方位角位移的大变化，使用轴对称旋流。与手性物质的对映选择性络合提供了电泳迁移率的差异。计算工作将集中于扩散、场强、几何和旋流的影响。浮力或电流体动力二次流也将被评估。电泳细胞将在NIST制造，实验将集中在除草剂对映体的分离上。该项目可能会为商业生产和开发测试带来一种经济的手性分离替代方案。这将减少手性农药的施用水平和环境负担。

CTS - 9613241 Arne Pearlstein University of Illinois Urbana-Champaign ABSTRACT The project is a combined computational and experimental effort at developing a generic field-enhanced continuous electrophoretic separation of chiral pesticides. The process is three-dimensional, and amplifies small electrophoretic mobility difference into large variations in azithumal displacement in an annulus, using an axisymmetric swirl flow. Enantioselective complexation with a chiral species provides the electrophoretic mobility difference. Computational work will focus on the effects of diffusion, field strength, geometry and swirl. Buoyant or electrohydrodynamic secondary flows will also be evaluated. The electrophoresis cell will be fabricated at NIST, where experiments will focus on the separation of herbicide enantiomers. The project may lead to an economical alternative to chiral separation for both commercial production and developmental testing. This will reduce the application levels of chiral pesticides and their environmental burden.