CAREER: Osmotically-Driven Intracellular Transport Phenomena

9624619 Edwards这个职业发展计划包括研究和教育活动。该研究的目的是分析细胞体积对渗透胁迫条件的反应，包括非稳态细胞内运输，细胞内运输现象对细胞骨架蛋白凝胶结构和内部细胞器阻塞的依赖，以及溶质在内外膜上的吸收和分配到细胞器。预期的主要应用是人类、动物和植物细胞的低温保存。其基本原理是，增加了解将提高预测能力和设计适当的冻融循环。教育计划的目标是将传质基础知识，包括新的应用，纳入本科和研究生课程。此外，还计划编写一本生物质量传输教材。＊＊＊

9624619 Edwards This career development plan contains both research and education activities. The objective of the research is to develop an analysis of cell volume response to osmotic stress conditions that include unsteady-state intracellular transport, dependence of intracellular transport phenomena on the gel structure of cytoskeletal proteins and on the occlusions posed by internal organelles, and absorption of solutes onto external and internal membranes and partitioning into organelles. The primary anticipated application is cryopreservation of human, animal and plant cells. The rationale is that increased understanding will improve the predictive capability and design of appropriate freeze-thaw cycles. The goal of the educational plan is incorporate knowledge of mass transfer fundamentals, including new applications, into undergraduate and graduate curricula. Also, a textbook on Mass Transport in Biology is planned. ***