CAREER: Computer Modeling of Bone

9625030凯文的目标是在加州大学伯克利分校通过将本科生和研究生的研究与教学相结合，开发一个全面的矫形外科生物力学课程。拟议的计算机研究的发展将通过引入以实验室为基础的计算机项目的方式纳入现有的生物力学本科生课程。其他教学目标包括：开发一门新的计算生物力学研究生课程；为本科生和研究生推出研究研讨会，以帮助他们选择职业；将本科生和毕业生纳入拟议的研究；扩大加州大学伯克利分校机械工程系和加州大学旧金山分校整形外科系之间的研究和教学合作；以及为本科生生物力学课程开发实验程序的短片和基于光盘的教科书。主要的研究目标是开发一个用于研究松质骨生物力学的计算框架，并使用该框架来解决关于这种复杂生物组织的力学行为的一些基本问题。这些问题主要涉及组织在微观结构水平上的力学行为与整个标本水平上的机械性能之间的关系。具体地说，将研究试件内最大应力和应变位置与骨小梁孔隙度和结构之间的关系以及伴随这些趋势的破坏模式。还将确定这些趋势对解剖位置、损伤、骨丢失、组织特性变化以及加载方式(如拉伸、压缩、剪切、离轴和多轴)的敏感性。与劳伦斯利弗莫尔国家实验室的研究人员合作，将开发出执行40个松质骨的三维高分辨率有限元模型的能力，在包含多达1亿个单元的模型上使用大规模并行计算。对于另外40个取自一系列解剖部位的骨小梁标本，该建模技术将根据实验数据进行前瞻性的验证。然后将进行有限元参数研究，以解决具体的研究目标。该项目的结果将与小梁骨、衰老、疾病、创伤、药物开发和人工骨替代品的生物学形式-功能关系相关。计算技术的发展还将提高对任何几何复杂结构进行应力分析的能力，甚至超越生物工程领域。***

9625030 Keaveny The goal is to develop a comprehensive program in orthopaedic biomechanics at UC Berkeley by integrating research with teaching at both the undergraduate and graduate levels. Developments from the proposed computatinal research will be incorporated into an existing undergraduate class in biomechanics by way of introducing a laboratory-based computer project. Other teaching objectives include: development of a new graduate course in computational biomechanics; introduction of research seminars for undergraduates and graduates to assist in career choices; inclusion of undergraduates and graduates in the proposed research; expansion of research and teaching collaboration between the Departments of Mechanical Engineering at UC Berkeley and Orthopaedic Surgery at UCSF; and development of short videos of experimental procedures and a CD ROM-based textbook for the undergraduate biomechanics class. The major research goal is to develop a computational framework for the study of the biomechanics of trabecular bone and to use this framework to address a number of fundamental issues on the mechanical behavior of this complex biological tissue. These issues are concerned primarily with the relationships between the mechanical behavior of tissue at the microstructural level vs. the mechanical properties at the whole specimen level. Specifically, relationships between locations of maximum stress and strain within the specimen vs. trabecular porosity and architecture will be investigated as well as the failure modes that accompany these trends. The sensitivity of these trends to anatomic site, damage, bone loss, variations in tissue properties, and loading modes such as tension, compression, shear, off-axis, and multi- axis will also be determined. In collaboration with researchers from Lawrence Livermore National Laboratory, capabilities will be developed to perform three- dimensional "high-resolution" finite element models of 40 trabecular bone spe cimens, using massively parallel computation on models with up to 100 million elements. The modeling technique will be prospectively validated against experimental data for an additional 40 specimens of trabecular bone taken from a range of anatomic sites. Finite element parameter studies will then be performed to address the specific research objectives. Results from this project will be relevant to biological form-function relations in trabecular bone, aging, diseasae, trauma, drug development, and artificial bone substitutes. The computational developments will also improve the ability to perform stress analyses on any geometrically complex structure, even beyond the realm of bioengineering. ***