NSF Minority Postdoctoral Research Fellowship for FY 1996

这一行动为1996年国家科学基金会少数民族博士后研究奖学金提供了资金。该奖学金支持发育生物学领域的研究和培训。研究和培训计划涉及线虫精子与卵母细胞相互作用所需的精子成分，线虫是广泛用于正常发育研究的重要模型系统。该项目使用了几种基因，当这些基因发生突变时，产生了细胞学上正常的、活动的精子，即使在接触后也不能使卵母细胞受精。这些突变似乎扰乱了精子-卵母细胞的识别、黏附或融合。在任何其他后生动物中都没有描述过同等的突变体。这些方法包括遗传学方法、细胞生物学方法和分子生物学方法，以了解这些基因及其突变形式。

This action funds an NSF Minority Postdoctoral Research Fellowship for 1996. This fellowship supports research and training in the area of developmental biology. The research and training plan addresses the sperm components required for sperm-oocyte interactions in C. elegans, an important model system used extensively in studies of normal development. The project uses several genes that when mutated produce cytologically normal and motile sperm that cannot fertilize oocytes even after contact. These mutations seem to disrupt either sperm-oocyte recognition, adhesion, or fusion. Equivalent mutants have not been described in any other metazoan. The approaches include genetic, cell biological, and molecular biological ones to gain an understanding of these genes and their mutant forms.