Bone Marrow Tissue Engineering for Ex Vivo Hemopoiesis/ Lymphopoiesis and Neural Modulation

9631670吴这个项目应该会导致对骨髓微环境、神经递质的作用以及调节造血和淋巴生成的基因和分子有一个基本的了解。所获得的信息将被用于制定体外骨髓模拟工程的策略。它最终将带来一种新的骨髓技术，用于治疗血液病的临床应用。此外，基于这些信息设计的骨髓生物反应器应该是进一步描述造血微环境以及检查药物疗效、毒性和致病性的非常有价值的工具。***

9631670 Wu This project should lead to a fundamental understanding of the marrow microenvironment, the role of neurotransmitters, and the genes and molecules regulating hemopoiesis and lymphopoiesis. The information obtained will be used to formulate strategies for engineering ex vivo bone marrow mimicry. It will ultimately lead to a novel bone marrow technology for clinical applications in treating hematological disorders. Moreover, design of a bone marrow bioreactor based on this information should be an extremely valuable tool for further delineating the hemopoietic microenvironment, and for examining drug efficacy, toxicity, and pathogenicity. ***