Kinetic and Mechanistic Studies of Highly Reactive Species Containing Electron-Deficient Main Group Atoms, and the Synthesis of Novel Molecules

在化学系有机动力学项目的资助下，华盛顿大学(圣路易斯)的彼得·P·加斯帕教授将研究含有缺乏电子的主族原子的高活性物种。这是CHE-9108130奖的续展。最近的工作导致了制造新型缺电子卡宾类似物的方法的发现，亚膦(RP)，形式上代表一价磷，Gaspar的小组多年来一直参与硅烯化学。该项目将尝试在不同的原子上产生具有电子缺陷的高活性物种：硅烯、锗、锡烯、硼烯和铝烯。该项目将把有机化学的机械论思想扩展到整个元素周期表的成键和断键过程的预测和合理化。其他新物种，如香叶烯和亚膦硫属化合物，将提供机械洞察力，并有可能提供合成用途。有机化学有着丰富的详细研究高活性物种的历史，这些物种是许多化学反应的中间体，并利用这些研究来预测新的有用的化学。这个项目将研究一系列相关的高能和活性物种，涉及的原子传统上不被认为是有机化学家全部技能的一部分。它将利用有机化学的基本原理，将我们对化学行为细节的理解扩展到元素周期表的许多其他区域。

With funding from the Organic Dynamics Program of the Chemistry Division, Professor Peter P. Gaspar of Washington University (St. Louis) will study highly reactive species containing electron-deficient main group atoms. This is a renewal of Award CHE-9108130. Recent past work led to discovery of ways to make the novel electron deficient carbene analogs, phosphinidenes (RP), representing formally monovalent phosphorus, and Gaspar's group has been involved in silylene chemistry for many years. This project will involve attempts to generate highly reactive species with electron deficiency on diverse atoms: silylenes, germylenes, stannylenes, borylenes, and aluminylidenes. The project will extend the mechanistic ideas of organic chemistry to the prediction and rationalization of bond-making and bond-breaking processes across the periodic table. Other new species such as germenes and phosphinidene chalcogenides will provide mechanistic insight and, potentially, synthetic utility. Organic chemistry has a rich history of detailed study of highly reactive species, which are intermediates in many chemical reactions, and of using such studies to predict new and useful chemistry. This project will examine a series of related highly energetic and reactive species involving atoms not traditionally considered part of the organic chemist's repertoire. It will use the rationales of organic chemistry to extend our understanding of details of chemical behavior into many other regions of the periodic table.