Proposal to Upgrade the UC Berkeley College of Chemistry NMR Facility

化学研究仪器和设施(CRIF)计划的这一奖项将帮助加州大学伯克利分校的化学系获得核磁共振。该设备将加强以下领域的研究：(1)有机合成在包括螺旋核素和大环肽酶抑制剂在内的生物学问题上的应用；(2)有机金属化合物的合成和探索化学及其反应机理的研究；(3)有机合成方法和天然产物的全合成，包括杂环酸和二硫杂环己烷；(4)生物体系中的分子识别和催化，以及这些研究在设计和合成具有新生物学性质的新分子方面的应用；以及(5)探索合成，新型无机体系的结构和反应性研究，包括过渡金属-硅化学和金属介导的电荷传输聚合物的路线。核磁共振波谱是化学家用来解释分子结构的最有力的工具。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱是必不可少的。这些核磁共振研究的结果在聚合物、催化和生物学等领域是有用的。

This award from the Chemistry Research Instrumentation and Facilities (CRIF) Program will assist the Department of Chemistry at the University of California Berkeley acquire a NMR. This equipment will enhance research in a number of areas including the following: (1) application of organic synthesis to biologial problems including helix nucleators and macrocyclic peptidase inhibitors (2) synthesis and exploratory chemistry of organometallic compounds and the investigations of their reaction mechanisms (3) organic synthesis methodology and total synthesis of natural products including zaragozic acid and dictyoxetane (4) molecular recognition and catalysis in biological systems and applications of these studies to the design and synthesis of new molecules with novel biological properties, and (5) exploratory synthetic, structural and reactivity studies on novel inorganic systems including transition metal-silicon chemistry and metal-mediated routes to charge-transporting polymers. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in the areas such as polymers, catalysis, and in biology