CAREER: Metal-Mediated Formation and Cleavage of Phosphorus-Carbon Bonds

这个职业奖在无机、生物无机和有机金属化学项目中支持达特茅斯学院的David S. Glueck的研究和教育计划。本研究的目的是了解磷-碳（P-C）键的形成，以开发金属催化合成手性磷化氢，并设计抗P-C键断裂的磷化氢配体。对有机磷的还原消除和氧化加成反应机理的研究将指导手性催化剂的开发，并验证具有供电子取代基的芳基膦抗降解的假设。将开设一门新的课程，通过跨学科的视角来研究几种顶级工业化学品，以提高文科学生的科学素养。将探讨这些化学品的工业化学、经济和环境影响。

This CAREER Award in the Inorganic, Bioinorganic and Organometallic Chemistry Program supports the research and education plans of David S. Glueck of Dartmouth College. The goal of the proposed research is to understand the formation of phosphorous-carbon (P-C) bonds to develop metal-catalyzed syntheses of chiral phosphines and to design phosphine ligands resistant to P-C bond cleavage. Mechanistic studies of reductive elimination and oxidative addition reactions with organophosphorous species will guide chiral catalyst development and test the hypothesis that arylphosphines with electron-donating substitutents will resist degradation. A new course will be developed to improve the scientific literacy of liberal arts students by taking an interdisciplinary look at a few top industrial chemicals. The industrial chemistry, economics, and environmental impacts of these chemicals will be explored.