Molecular Genetic Analysis of Life Span Variation in Drosophila melanogaster

9707706 服务 该项目的目标是确定控制果蝇（Drosophila melanogaster）衰老的基因。 果蝇是一种“模式”生物，多年来一直被用来研究基本的遗传问题。 在这项研究中使用的苍蝇是来自种群，由于在实验室中的选择性繁殖，平均寿命有两倍以上的差异。 这种寿命的差异是由于衰老速度的差异。 经历更快衰老的苍蝇寿命更短。 该项目将提供有关这些果蝇种群之间寿命和衰老差异的基因数量的数据。 它也将使这些基因的大致染色体位置的鉴定。 这个项目将有助于我们了解衰老的分子和遗传基础。 由于所有动物在分子和细胞水平上都有许多基本相似之处，因此该项目可能提供广泛适用于许多经历衰老和衰老的动物物种的结果，包括人类。

9707706 Service The goal of this project is to identify genes that control senescence in the fruit fly, Drosophila melanogaster. The fruit fly is a "model" organism that has been used for many years to investigate fundamental genetic questions. The flies to be used in this study are from populations that have a more than two-fold difference in average life span as a result of selective breeding in the laboratory. This difference in life span is due to differences in rates of senescence. Flies that undergo more rapid senescence have shorter life spans. This project will provide data on the number of genes responsible for differences in life span and senescence between these fly populations. It will also enable identification of the approximate chromosomal locations of these genes. This project will contribute to our understanding of the molecular and genetic basis of aging. Because all animals share many basic similarities at the molecular and cellular levels, this project may provide results that are broadly applicable to the many animal species that undergo aging and senescence, including humans.