A Dendritic Origin of Bistability of Motoneuron Firing Patterns

维多利亚·布斯·莱曼的提案摘要《运动神经元放电模式的双稳态起源的树突起源》(提案#：IBN-9722946)在对来自神经系统其他部位的刺激作出反应时，脊髓中的神经元，称为运动神经元，产生一种称为动作电位的电信号，该电信号被传递到肌肉纤维并诱导收缩。通过这种方式，运动神经元的动作电位放电模式调节肌肉运动。在自然产生的神经递质5-羟色胺存在的情况下，实验者观察到运动神经元发射被认为影响肌肉活动的复杂的动作电位模式。运动神经元内负责产生动作电位的细胞机制是众所周知的，这使得复制运动神经元行为的数学模型的发展成为可能。这项建议的目的是通过研究运动神经元的数学模型来研究5-羟色胺诱导的复杂放电行为产生的细胞机制。特别令人感兴趣的是，这种复杂的行为是位于神经元不同部分的机制相互作用的结果，其中一个部分以前被认为与动作电位的产生无关。

Victoria Booth Layman's abstract for proposal titled "A dendritic origin of bistability of motoneuron firing patterns" (proposal #: IBN- 9722946) In response to stimuli from the rest of the nervous system, neurons in the spinal cord, called motoneurons, generate an electrical signal called an action potential that is transmitted to muscle fibers and induces contraction. In this way, the pattern of action potential firing by motoneurons regulates muscle movement. In the presence of the naturally-occuring neurotransmitter serotonin, experimentalists have observed motoneurons firing complex patterns of action potentials that are believed to affect muscle activity. The cell mechanisms within motoneurons responsible for the generation of action potentials are sufficiently well known to allow the development of mathematical models that replicate motoneuron behavior. The goal of this proposal is to investigate the cell mechanisms underlying the generation of the serotonin-induced complex firing behaviors by studying mathematical models of motoneurons. Of particular interest is the suggestion that the complex behaviors are a result of the interaction of mechanisms located in different segments of the neuron, where one segment was previously thought to be uninvolved in action potential generation.