Exo Selective and Enantioselective Transition-Metal Mediated Cycloaddition Reactions

本研究的重点是钴肟和Cosalen取代的1，3-二烯基络合物在(4+2)环加成反应中的应用。将开发对映体和外选择性环加成反应以及外选择性杂(4+2)路线合成二氢吡喃的方法学。所得产品将作为中间体，用于构建含有天然产物的低分子化合物和二氢吡喃。通过这一奖项，有机和高分子化学项目支持维克森林大学化学系的马克·E·韦尔克博士的研究。韦尔克教授将专注于开发利用C-C键形成、环加成反应制备含碳环的新方法。这样形成的产物是制备具有有趣生物学特性的天然产品的重要中间体。

The focus of this research is the use of cobaloxime and cosalen substituted 1,3-dienyl complexes in (4 + 2) cycloaddition reactions. Methodology for enantio- and exo-selective cycloadditon reactions as well as exo-selective hetero (4 + 2) routes to dihydropyrans will be developed. The resulting products will serve as intermediates for the construction of decalone and dihydropyran containing natural products. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Mark E. Welker of the Department of Chemistry at Wake Forest University. Professor Welker will focus his work on developing new methodology for the preparation of carbon-containing rings using C-C bond forming, cycloaddition reactions. The products thus formed are important intermediates for the preparation of natural products having interesting biological properties.