Impact of artificial extracellular matrix on fibroblast functions (B04)

联合Anderegg和A. Saalbach打算通过sHA GAG衍生物抑制过量的TGF-β1，并在博来霉素诱导的皮肤纤维化模型中对其进行测试。另一方面，他们计划使用含肝素的aECM向TGF-β1缺乏的条件（即db/db小鼠中延迟的伤口愈合）提供外源性TGF-β1。最后，含有sHA的水凝胶负载肝素结合表皮生长因子（HB-EGF）-将用于研究db/db小鼠和离体猪皮肤模型中的表皮增殖和真皮重塑。

U. Anderegg and A. Saalbach intend to scavenge excess of TGF-β1 by sHA GAG derivatives and test them in the model of bleomycin-induced skin fibrosis. On the other hand, they plan to provide exogenous TGF-β1 using heparin-containing aECM to conditions of TGF-β1 deficiency i.e. delayed wound healing in db/db mice. Finally, sHA-containing hydrogels loaded with heparin-binding epidermal growth factor (HB-EGF) – will be used to study epidermal proliferation and dermal remodeling in db/db mice and the ex vivo pig skin model.