Dissertation Enhancement: Crystallographic Studies of the Flavoprotein NADH Oxidase, A Key Enzyme in Streptococcal Energy Metabolism

9803674 Claiborne该奖项将支持维克森林大学Al Claiborne教授的博士生Conn Mallett先生与日本大阪大学蛋白质研究所Tomitake Tsukihara教授合作进行论文研究。Mallett先生将在日本花12个月的时间进行晶体学研究，重点研究黄素蛋白NADH氧化酶的结构，这是链球菌能量代谢的关键酶。利用东道国研究所的大分子晶体学设备将提供结构信息，这将补充目前对酶的动力学和氧化还原特性的研究。这项研究将增加我们对黄蛋白结构和功能的基本认识，并为结构信息应用于设计抗人类链球菌感染的新治疗分子提供了潜力。此外，该项目促进了美国和日本互补实验室之间的合作，并为美国研究生提供了国际研究经验。＊＊＊

9803674 Claiborne This award will support Mr. Conn Mallett, a Ph.D. student under Professor Al Claiborne at Wake Forest University, to conduct dissertation research in collaboration with Professor Tomitake Tsukihara of the Institute for Protein Research, Osaka University, Japan. Mr. Mallett will spend 12 months working in Japan on crystallographic studies focused on the structure of the flavoprotein NADH oxidase, a key enzyme in streptococcal energy metabolism. Use of the host institute's macromolecular crystallography facility will provide structural information which will complement current studies on the kinetic and redox properties of the enzyme. This research will add to our fundamental understanding of flavoprotein structure and function, and offers the potential for application of structural information to the design of new therapeutic molecules for fighting streptococcal infection in humans. Moreover, this project enables collaboration between complementary laboratories in the United States and Japan and provides international research experience for an American graduate student. ***