FASEB Conference: Intracellular RNA Sorting, Transport and Localization, to be held in Snowmass, Colorado, June 6-11, 1998

9805557该奖项为FASEB会议提供部分支持，该会议侧重于转录后RNA加工、转运和靶向的多学科领域。由于集中于各种分子、细胞和发育问题的研究信息的汇集，这一领域的重要性已经变得明显。在过去的15年中，已经在脊椎动物和无脊椎动物的多种细胞类型中发现了70多种细胞内定位rna，范围从卵母细胞到上皮细胞到神经元和胶质细胞。此外，不同种类的蛋白质被定位的RNA编码，包括转录因子、RNA结合蛋白、细胞骨架蛋白、细胞内信号分子和分泌的生长因子。现在很清楚，mrna靶向特定的细胞内位置在生物过程中起着关键作用，包括卵母细胞极性的建立、早期胚胎分化、体细胞极化和功能、突触生长和脊椎动物神经系统的可塑性。会议的目标是在1994年和1996年举行的两次类似和成功的会议的基础上，汇集在这一领域具有广泛观点和背景的研究人员和学生。会议将探讨共同的主题和问题，包括(1)RNA定位在建立胚胎细胞谱系和细胞极性中的作用，(2)将mrna靶向特定细胞内位置的顺式作用信号和反式作用因子，(3)负责这种靶向的传递系统，(4)将mrna锚定在目标位置的机制，(5)靶向位置的表征和范围，(5)靶向位置的特征和范围。(6)细胞外和细胞内信号系统参与mRNA的转运和靶向，(7)RNA在核膜上的转运，(8)RNA分选对细胞功能的影响。会议资源的很大一部分将用于支持研究生和年轻研究人员的出席。

9805557 The award provides partial support for a FASEB Conference that focuses on the multidisciplinary area of post-transcriptional RNA processing, transport and targeting. The importance of this area has become evident as a result of the convergence of information from studies focusing on a variety of molecular, cellular and developmental questions. During the past fifteen years over seventy intracellularly localized RNAs have been identified in a diversity of cell types in both vertebrates and invertebrates, ranging from oocytes to epithelial cells to neurons and glia. In addition, diverse classes of proteins are encoded by localized RNAs, including transcription factors, RNA binding proteins, cytoskeletal proteins, intracellular signaling molecules and secreted growth factors. It is now clear that the targeting of mRNAs to particular intracellular locations plays a key role in biological processes that include the establishment of oocyte polarity, early embryonic differentiation, somatic cell polarization and function, synapse growth, and plasticity in the vertebrate nervous system. The goal of the conference is to build upon two similar and successful conferences held in 1994 and 1996 by bringing together researchers and students with a wide range of perspectives and backgrounds in this area. The conference will explore common themes and questions that include (1) the role of RNA localization in establishment of embryonic cell lineage and cell polarity, (2) cis-acting signals and trans-acting factors that target mRNAs to specific intracellular locations, (3) the delivery systems responsible for this targeting, (4) the mechanism that anchors mRNAs at target locations, (5) the characterization and extent of targeting sites, (6) the involvement of extracellular and intracellular signaling systems in mRNA transport and targeting, (7) transport of RNA across the nuclear envelope, and (8) the effects of RNA sorting on cell functions. A significan t portion of conference resources will be used to support the attendance of graduate students and young investigators.