GOALI: Selectivity Crystallization of Molecules on Solid Surfaces Using Engineered Self-Assembled Monolayers as Nanotemplates

摘要CTS-9871798 A. Couzis/纽约市立大学 这项研究是城市学院化学工程系和杜邦公司中央研究和开发部门之间的联合合作。 本研究的目的是设计固体表面纳米模板的异质结晶作为种子的一种形式的结晶材料，可以存在于几个多晶型形式。 然后，这些多晶型物特异性晶种用于控制本体工业结晶器中的选择性结晶。 该方法采用自组装硅烷或有机硫单分子膜，其共价连接到固体载体上，以用化学部分官能化表面。 以使得表面模拟所需多晶型物的结晶面的方式选择所述部分。 以这种方式，该面在表面上成核，并且所需多晶型物的成熟晶体生长。 将研究两个系统，碳酸钙的无机多晶型物方解石和球文石，以及氨基酸甘氨酸的α和γ形式。在这些系统中的每一个中，将构造用于选择性结晶的模板。 该研究解决了杜邦公司在其药物和农业化学工业中对选择性多晶型结晶的要求，并在学术上为定制表面的分子工程设计的发展做出了贡献。 在这项研究工作下开发的工程纳米模板将用于杜邦公司制造种子的设备的设计、建造和测试。 因此，这项研究工作代表了纳米结构的直接使用。

ABSTRACT CTS-9871798 A. Couzis/CUNY This research is a joint collaboration between the Department of Chemical Engineering at the City College and the Central Research and Development Division of DuPont. The objective of the research is to design solid surface nanotemplates for the heterogeneous crystallization as seeds of one form of a crystalline material which can exist in several polymorphic forms. These polymorph specific seeds are then used to control the selective crystallization in a bulk industrial crystallizer. The approach employs using self assembled silane or organosulfur monolayers which covalently link to solid supports to functionalize surfaces with chemical moities. The moities are selected in such a way that the surface mimics a crystalline face of the desired polymorph. In this way this face nulceates on the surface, and the mature crystal of the desired polymorph grows. Two systems will be studied, the inorganic polymorphs calcite and vaterite of calcium carbonate, and the alpha and gamma forms of the amino acid glycine. In each of these systems, templates will be constructed for selective crystallization. The research addresses Dupont's requirements for selective polymorphic crystallization in their drug and agrochemical industries, and academically contributes to the development of molecular engineering designs for tailoring of surfaces. The engineered nanotemplates developed under this research effort, will be utilized in the design, construction, and testing at DuPont of a device to fabricate seeds. This research effort there fore represents a directed use of nanostructures.