Smart biomaterials

该项目旨在设计可光触发的材料，通过使用不稳定于紫外光的笼状配体来动态呈现和/或释放生物黏附基序。我们推测，这些紫外线触发的笼式生物黏附配体将在体外和体内提供对细胞-材料相互作用的精确控制。我们建议开发两个生物材料平台(表面和水凝胶)，以研究细胞过程中时空黏附的影响。所提出的研究将为精确的生物功能时空控制提供通用的生物材料策略。然后，这些创新的生物材料将被用来提供关于细胞-生物材料在体外和体内相互作用的新见解。此外，对工程可触发水凝胶的关注为转化为许多生物技术和生物医学应用提供了一条途径。

This project aims to engineer phototriggerable materials to dynamically present and/or release bioadhesive motifs via the use of UV-labile caged ligands. We hypothesize that these UV-triggerable caged bioadhesive ligands will provide precise control over cell-material interactions in vitro and in vivo. We propose to develop two biomaterial platforms (surfaces, hydrogels) with triggerable adhesive RGD ligands in order to investigate the effects of spatiotemporal adhesion in cell processes.The proposed research will generate a general biomaterial strategy for precise spatiotemporal control of biological functionalities. These innovative biomaterials will then be used to provide new insights on cell-biomaterial interactions in vitro and in vivo. Furthermore, the focus on engineering triggerable hydrogels provides a pathway for translation into many biotechnological and biomedical applications.