Surfactant and Emulsification Properties of Amphiphilic Linear - Dendritic Hybrid Co-polymers-Structure-Function Rules and Potential for Enhanced Drug Delivery

本课题提出了两亲线型-枝晶杂化共聚物的制备与研究。这些材料的主要特征包括具有可调节疏水性的枝状核，表面有亲水性共聚物。将进行结构-功能研究，以最大限度地发挥这些分子的表面活性剂和乳化性能。乳化性能将包括在水中稳定油乳的能力，从而能够溶解大量具有生物活性但不溶于水的药物。通过这个奖项，有机和大分子化学项目支持匹兹堡大学Toby M. Chapman教授的研究。查普曼教授试图构建分子胶囊，将不溶于水的物质带入水溶液中。研究这些分子在结构变化时性质的变化，将使人们能够精细地调整这些结构，以便允许药物分子在最佳位置进行定向释放。

This project proposes the preparation and study of amphiphilic linear-dendritic hybrid copolymers. Key features of these include a dendritic core with adjustable hydrophobic properties coupled with hydrophilic copolymers at the surface. Structure-function studies will be carried out to maximize the surfactant and emulsifying properties of these molecules. Emulsification properties will include the ability to stabilize oil emulsions in water giving an ability to solubilize significant amounts biologically active but water insoluble drugs.With this Award, the Organic and Macromolecular Chemistry Program supports the research of Professor Toby M. Chapman of the University of Pittsburgh. Professor Chapman seeks to construct molecular capsules that will carry water insoluble substances into aqueous solutions. Study of the variation in these molecules properties as their structures are changed will allow one to finely tune these structures in order to permit the carriage of drug molecules for site-directed release at the optimal location.