RUI: Role of EPH Molecules in Cochlear and Vestibular Neurite Outgrowth

在发育过程中，神经元(神经细胞)会产生长的突起，称为突起，它可以与大脑中的目标细胞建立远距离、高度特异的连接。许多研究表明，特定的分子是这种生长的标志物或调节器。其中一类分子被称为‘Eph’家族。该项目使用分子和解剖学技术来显示神经细胞膜中的分子受体分子何时何地与Eph分子结合。一种新的方法结合了体外和体内的研究，使用生物测定和突变小鼠来发现结合的调节如何启动、抑制或修改发育中的哺乳动物耳朵神经中神经突起的生长和定向标题。结果对于理解主要感觉通路的形成以及一般的发育过程都将是重要的。这个芮氏项目也对教育产生了很大的影响，通过培养本科生进行研究。

During development, neurons (nerve cells) produce long extensions called neurites, which can make long-distance, highly specific connections to target cells in the brain. Many investigations have shown that particular molecules act as markers or regulators of this outgrowth. One of the classes of molecules is known as the 'Eph' family. This project uses molecular and anatomical techniques to show when and where the molecular receptor molecules in nerve cell membranes bind to the Eph molecules. A novel approach combines studies in vitro and in vivo, using bioassays and mutant mice to discover how the regulation of the binding may initiate, inhibit or modify the outgrowth and directional heading of neurites in the nerve from the developing mammalian ear. Results will be important to understanding the formation of a major sensory pathway, as well as for developmental processes in general. This RUI project also has a strong impact on education, by training undergraduates in research.