U.S.-Japan Joint Seminar: Neuroplasticity, Development and Steroid Hormone Action

9909858该奖项支持美国科学家参加将于2000年9月29日至10月3日在夏威夷举行的关于神经可塑性、发育和类固醇激素作用的美日研讨会。联合组织者是科罗拉多州立大学博尔德的罗伯特·汉达教授和日本东京都神经科学研究所的林信治教授。本次研讨会的重点将是阐明类固醇激素在动物整个生命周期中对大脑中神经可塑性变化的影响。将讨论的五个主要主题包括：1)下丘脑和LHRH神经元系统的发育和分化；2)类固醇依赖的脑分化；3)激素分泌的中枢调节；4)成熟大脑中的类固醇激素和神经可塑性；5)类固醇调节细胞生长和存活的机制。类固醇激素是中枢神经系统使用的细胞间通信网络的关键调节器。这些简单的激素能够影响几乎所有的神经功能，从发育过程中神经元及其连接的维护和组织，到成年后神经元的活动和功能，再到神经元在衰老和神经病理过程中的死亡。类固醇敏感神经回路与生殖功能、应激反应、情绪、攻击性、认知、活动、摄食等有关。研讨会组织者特别努力让年轻的研究人员既作为参与者又作为观察员。与日本专家在这一领域交换想法和数据将使美国参与者能够推进他们自己的工作，并将为未来的合作项目奠定基础。预计会议记录的传播将发表在《神经内分泌学前沿》杂志上。这些信息也将在网站http://lamar.colostate.edu/~bhanda/us-japan.htm.上查阅

9909858HandaThis award supports the participation of American scientists in a U.S.-Japan seminar on Neuroplasticity, Development and Steroid Hormone Action, to be held in Hawaii from September 29 to October 3, 2000. The co-organizers are Professors Robert Handa at Colorado State University, Boulder and Professor Shinji Hayashi at the Tokyo Metropolitan Institute of Neuroscience in Japan. The focus of this seminar will be in elucidating the effects of steroid hormones on neuroplastic changes in the brain throughout the lifespan of the animal. The five major topics to be discussed include: 1) development and differentiation of the hypothalamus and LHRH neuronal systems; 2) steroid dependent brain differentiation; 3) central regulation of hormone secretion; 4) steroid hormones and neuroplasticity in the mature brain; and 5) steroid mediated mechanisms of cell growth and survival.Steroid hormones are key modulators of the intercellular communications network used by the central nervous system. These simple hormones have the capacity to influence virtually all neural functions from the maintenance and organization of neurons and their connections during development to the activity and function of neurons in adulthood, to the death of neurons during aging and neuropathology. Steroid sensitive neural circuits are implicated in reproductive function, stress responses, emotion, aggression, cognition, activity, feeding and others. The Seminar organizers have made a special effort to involve younger researchers as both participants and observers. The exchange of ideas and data with Japanese experts in this field will enable U.S. participants to advance their own work, and will set the stage for future collaborative projects. It is anticipated that dissemination of proceedings of the meeting will be published in the journal "Frontiers in Neuroendocrinology. The information will also be available on the website http://lamar.colostate.edu/~bhanda/us-japan.htm.