New Experimental Challenges in Organofluorine Chemistry; A New Dimension in Elemental Fluorine

本研究项目探讨了多种有机氟化合物的合成。实现这一目标的主要手段是使用氟分子，为此已经设计了新的程序，可以研究其与各种底物的反应。此外，这些新材料的数量将大大增加。在以前的支持期间制备的许多新物质已被证明具有适用于许多应用的有用特性。进一步的研究将扩大这些反应的范围，并且由于底物类型数量的增加，很可能会发现新的化学反应。通过这个奖项，有机和大分子化学项目支持德克萨斯大学奥斯汀分校Richard J. Lagow教授的研究。Lagow教授的研究目标是将氟原子纳入有机分子结构的新方法和反应，通常是通过取代氢原子。该项目的部分预期进展集中在使用一种新型反应器，以便在受控条件下方便和安全地使用氟分子。这样，可以接触到氟化的分子的种类就会大大增加。这些新的有机氟化合物的性质将被评估潜在的应用，其中有很多。例如，正在研究有机氟化合物作为血液替代品和敏感微电子装置的润滑剂。

This research project explores the synthesis of a wide variety of organofluorine compounds. The principal means by which this is achieved involves the use of molecular fluorine, for which new procedures have been devised that will permit the study of its reaction with a wide variety of substrates. In addition, much larger quantities of these new materials will be accessible. Many of the new substances prepared during the previous periods of support have been shown to possess useful properties that are appropriate for a number of applications. Further study will extend the scope of these reactions and because of the expansion in the number of substrate types, new chemistry may well be discovered. With this Award, the Organic and Macromolecular Chemistry Program supports the research of Professor Richard J. Lagow of the University of Texas at Austin. Professor Lagow's research targets new methods and reactions that incorporate fluorine atoms into the structure of organic molecules, typically by replacement of hydrogen atoms. Part of the anticipated progress in this project centers on the use of a novel reactor for the convenient and safe use of molecular fluorine under controlled conditions. In this way, the variety of molecules that can be exposed to fluorination will be expanded significantly. The properties of these new organofluorine compounds will be evaluated for potential applications, of which there are many. For instance, organofluorine compounds are being studied as blood substitutes and as lubricants for sensitive microelectronic devices.