Coordination and Bioinorganic Chemistry with Sulfur Ligands

特拉华大学化学系Charles G. Riordan博士得到无机、生物无机和有机金属项目的支持，开发聚硫醚硼酸盐的配位和生物无机化学。这些新配体的显著特征包括一个整体阴离子电荷，高度极化的硫醚供体，以及一个合成的多功能性，允许纳入一系列的硫取代基。该配体将作为辅助配体用于研究锌的生物无机化学，指导钴镍四面体配合物的反应性，并形成三种配位金属硫酸盐配合物。这些新物种的发展对于准确模拟含蛋白质和酶的金属活性位点具有重要意义。此外，这些研究将对一系列催化工业和生物过程的理解产生广泛的影响。

Dr. Charles G. Riordan, Chemistry Department, University of Delaware is supported by the Inorganic, Bioinorganic, and Organometallic Program to develop the coordination and bioinorganic chemistry of the poly(thioether)borates. Significant features of these new ligands include an overall anionic charge, highly polarizable thioether donors, and a synthetic versatility that permits inocrporation of a range of sulfur substituents. The ligands will be used as supporting ligands to investigate the bioinorganic chemistry of zinc, to direct the reactivity of tetrahedral cobalt and nickel complexes, and to form three coordinate metal thiolate complexes. The development of these new species is important to accurately model the active sites in metal containing proteins and enzymes. In addition, these studies will have broad implications to the understanding of a range of catalytic industrial and biological processes.