Impact of shear stress on vascular adaptations in humans

大动脉对于将血液和氧气输送到心脏和大脑等器官非常重要。控制这些重要动脉大小和功能的主要生理刺激是血流的大小，或者更准确地说，是动脉内壁所受的剪切力。我们开发了新的软件，可以对动脉壁速度、直径和血流量进行非侵入性评估。我们将评估动脉壁血流和剪切力的急性和慢性变化对动脉大小和功能的影响。我们还将开发新的软件，测量动脉壁行为的其他方面。这些基本的人体生理学研究对评估人类的动脉健康有直接的意义。

Large arteries are important for the delivery of blood and oxygen to organs such as the heart and brain. A primary physiological stimulus which controls the size and function of these crucial arteries is the magnitude of flow or, more accurately, shear force that the inner wall of the artery is exposed to. We have developed novel software which enables non-invasive assessment of arterial wall velocity, diameter and blood flow. We will assess the impact of acute and chronic changes in wall flow and shear on arterial size and function. We will also develop new software which measures other aspects of artery wall behaviour. These basic human physiology studies have direct implications for assessment of artery health in humans.