Enolate Aggregation and Reactivity

有了这个更新奖的有机和高分子化学计划是继续支持博士的工作安德鲁Streitwieser的化学系的加州大学伯克利分校。 这项研究的目的是扩展早期的工作涉及的平衡和动力学的烯醇化锂的聚集和它们的反应与有机卤化物，磺酸盐和羰基化合物含有活化的双键。 待探索的变量包括空间效应、共轭、可与锂离子配位的附加官能度、溶剂效应以及添加剂（如HMPA和胺）的效应。 研究涉及稀释的空气敏感溶液，将在一个独特的手套箱设施中进行，恒温样品保持器通过石英光纤电缆连接到外部计算机控制的紫外/维斯光谱仪。 理论计算将作为实验的补充。 这项工作所带来的更多的理解将有助于合成化学家设计出更好的方法来形成含有新的碳-碳键的有机分子。

With this renewal award the Organic and Macromolecular Chemistry Program is continuing its support for the work of Dr. Andrew Streitwieser of the Department of Chemistry of the University of California at Berkeley. The research aims to extend earlier work on the equilibria and kinetics involved in the aggregation of lithium enolates and their reactions with organic halides, sulfonates, and carbonyl compounds containing activated double bonds. Variables to be explored include steric effects, conjugation, added functionality which can coordinate with the lithium ions, solvent effects, and the effects of additives such as HMPA and amines. Research, which involves dilute air-sensitive solutions, will be done in a unique glove box facility, with a thermostated sample holder connected by quartz fiber-optic cables to an external computer-controlled uv/vis spectrometer. Experiments will be complemented by theoretical computations. The increased understanding expected to result from this work will aid synthetic chemists to devise improved ways to form organic molecules containing new carbon-carbon bonds.