Mesoscopic 2D- and 3D-scaffolds made of spider silk proteins providing bacteriostatic surfaces and anti-bacterial properties (A08)

本课题研究了分子和不同工艺参数对重组蜘蛛丝材料各项性能的影响。这些结果揭示了对丝绸组装的分子细节的见解。基于新的发现，它已经能够组装出具有自然机械性能的生物技术蜘蛛丝纤维。此外，有可能对植入物和导管进行涂层，以改善它们的生物相容性，并减少植入时不想要的副作用。最后，将自支撑的蜘蛛丝膜与纳米粘土复合，形成气体和水蒸气屏障。

In this project influences of molecular and varying processing parameters on distinct properties of recombinant spider silk materials have been investigated. The results reveal insights into molecular details of silk assembly. Based on the new findings it has been able to assemble biotech spider silk-like fibers with nature-like mechanical properties. Further, it has been possible to coat implants and catheters to improve their biocompatibility and to reduce unwanted side-effects upon implantation. Finally, self-supporting spider silk films were compounded with nanoclay to yield gas and water vapor barriers.