Breaching membrane barriers

本项目将致力于开发新型分子转运蛋白，将大分子物质运送到细胞或微生物内部。细胞膜是大分子的屏障。跨越这些障碍并将生物大分子递送到细胞中的能力代表了一项重大成就，为调节途径和引入生物标志物、治疗方法和研究工具提供了无限的机会。该项目的新型平台技术将基于稳定的环肽，将基因、蛋白质、探针或生物标志物递送到不同的细胞类型中，这些细胞类型可以监测或调节特定的途径，并转化为新的知识和特定的工业应用。

This project will endeavour to develop novel molecular transporters to deliver macromolecules inside cells or microorganisms. Cell membranes are barriers to macromolecules. The ability to cross these barriers and deliver biological macromolecules into cells represents a major achievement with endless opportunities to modulate pathways and to introduce biomarkers, therapeutics and research tools. The project’s novel platform technology would be based on stable cyclic peptides to deliver genes, proteins, probes or biomarkers into distinct cell types that can monitor or modulate specific pathways and be translated into new knowledge and specific industrial applications.