Purchase of a Gradient-Equipped Magic-Angle-Spinning Probe and Gradient Amplifier for Solid-State Nuclear Magnetic Resonance

这份来自化学研究仪器和设施（CRIF）项目的合同将使加州大学河滨分校的化学系能够为固态核磁共振（NMR）购买配备梯度的魔角旋转探针和梯度放大器。该设备将主要由初级教员Leonard J. Mueller使用，他的研究主要集中在(1)多维固态核磁共振实验的发展，用于高度C-13和N-15标记的生物样品的结构测定；(2)利用固态核磁共振技术研究核酸中氢键的结构。这种最先进的合成技术和固态核磁共振的结合将扩展结构生物学的能力，并首次允许对核酸中的氢键几何形状进行直接表征和系统研究。

This award from the Chemistry Research Instrumentation and Facilities (CRIF) Program will enable the Department of Chemistry at the University of California in Riverside to purchase a gradient-equipped magic-angle-spinning probe and gradient amplifier for solid-state nuclear magnetic resonance (NMR). This equipment will be used primarily by junior faculty member Leonard J. Mueller, whose research focuses on (1) the development of multidimensional solid-state NMR experiments for the structural determination of highly C-13 and N-15 labeled biological samples; and (2) structural studies of hydrogen bonding in nucleic acids via solid-state NMR. This combination of state-of-the-art synthetic techniques and solid-state NMR will expand the capabilities of structural biology and for the first time allow a direct characterization and systematic study of hydrogen bond geometries in nucleic acids.