Enantioselective Synthesis of b-amino acids

这项研究的重点是建立利用催化量的手性Lewis酸将氮亲核试剂与烯胺和亚烷基丙二酸酯对映体选择性加成的方法学。此外，还将开发一种互补的手性Lewis酸介导的方案，在该方案中，碳亲核试剂选择性地加成N-取代亚甲基丙二酸酯。所产生的方法学将用于制备具有生物活性的吲哚里西定和吡咯里西丁生物碱。获得这一奖项后，有机和高分子化学计划将支持北达科他州州立大学化学系的Mukund Sibi博士的研究。西比教授将开发制备光学活性β-氨基酸的新方法。这项研究可能会对制药和农业行业感兴趣的化合物和材料的合成产生更广泛的影响。

The focus of this research is to develop methodology for the enantioselective addition of nitrogen nucleophiles to enamides and alkylidene malonate using catalytic amounts of chiral Lewis acids. Further, a complementary chiral Lewis acid-mediated protocol in which carbon nucleophiles add selectively to N-substituted methylidene malonates will be developed. The resulting methodology will be used for the preparation indolizidine and pyrrolizidine alkaloids with biological activity.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Mukund Sibi of the Department of Chemistry at North Dakota State University. Professor Sibi will develop new methodology for the preparation of optically active beta-amino acids. The research could have broader impact in the synthesis of compounds and materials of interest to the pharmaceutical and agricultural industries.