U.S.-France Cooperative Research: Investigation of Novel Methods of Quadrupole SPLITT Separation

这项为期三年的美法合作研究奖的获得者包括克利夫兰诊所基金会的Maciej Zborowski和法国巴黎高等物理与工业化学学院的Mauricio Hoyos。该项目涉及一般的磁细胞分离和磁细胞分选过程。研究人员开发了一种研究规模，开放梯度，四极磁流分选机，以研究细胞在磁场中的行为，在流动的水介质。他们将进一步评估该系统及其在电流、批量磁选机系统上的分离潜力。美国研究者为这次合作带来了细胞分选和细胞分离设备方面的专业知识。这是由法国集团开发的流体动力学和分离方法（分流薄通道分离或SPLITT）的理论专业知识的补充。该项目将促进对流体动力学的理解，有助于细胞分离和分选以及在生物技术和生物医学研究中的应用。该奖项代表了美国方面向美国国家科学基金会和法国国家科学研究中心（CNRS）提出的联合提案。美国国家科学基金会将支付美国研究员和研究生的旅费和生活费。法国科学研究中心将支持法国研究人员访问美国。

0003787ZborowskiThis three-year award for U.S.-France cooperative research involves Maciej Zborowski at the Cleveland Clinic Foundation and Mauricio Hoyos of the Ecole Superieure de Physique et de Chimie Industrielle in Paris, France. The project addresses magnetic cell separation in general and magnetic cell sorting processes. The investigators have developed a research scale, open gradient, quadrupole magnetic flow sorter in order to study cell behavior in a magnetic field, in flowing aqueous media. They will further evaluate this system and its separation potential over current, batch-wise magnetic separator systems. The US investigator brings to this collaboration expertise in cell sorting and cell separation equipment. This is complemented by theoretical expertise in fluid dynamics and separation methods (split-flow thin channel separation or SPLITT) developed by the French group. The project will advance understanding of fluid dynamics that contribute to cell separation and sorting and applications in biotechnology and biomedical research. This award represents the US side of a joint proposal to the NSF and the French National Center for Scientific Research (CNRS). NSF will cover travel funds and living expenses for the US investigator and graduate student. The CNRS will support the visits of French researchers to the United States.