Applications of Bismuth Compounds in Organic Synthesis

在本项目中，将尝试使用各种铋化合物进行各种官能团转化，如环氧化物的裂解，环氧化物重排为羰基化合物和环氧多烯的环化。 这些反应将利用几种铋（III）化合物的刘易斯酸性以及铋（V）试剂的氧化能力。 鉴于人们对环境问题的认识不断提高，以及铋化合物的低毒性，该项目的成功完成将为这一目标做出重大贡献。有了这个奖项，有机和高分子化学计划的有机合成计划支持Ram S.伊利诺伊卫斯理大学的莫汉。 莫汉教授和他的化学系本科生将对铋化合物在合成有机化学中的应用进行系统的研究。 铋化合物由于其低毒性和容易以低成本获得而在有机合成中用作试剂是有吸引力的候选者。

In this project, a variety of functional group transformations such as cleavage of epoxides, rearrangement of epoxides to carbonyl compounds and cyclization of epoxy-polyenes will be attempted using various bismuth compounds. These reactions will exploit the Lewis acidity of several bismuth(III) compounds as well as the oxidizing power of bismuth(V) reagents. In light of increased awareness of environmental issues and the low toxicity of bismuth compounds, the successful completion of this project will make a significant contribution to this end.With this Award, the Organic and Macromolecular Chemistry Program's Organic Synthesis Program supports the research of Professor Ram S. Mohan of Illinois Wesleyan University. Professor Mohan and his undergraduate students of chemistry will undertake a systematic investigation of the applications of bismuth compounds in synthetic organic chemistry. Bismuth compounds are attractive candidates for use as reagents in organic synthesis because of their low toxicity and ready availability at low cost.