Acquisition of Circular Dichroism Spectrometer

在化学研究仪器和设施（CRIF）计划的支持下，南亚拉巴马大学化学系将获得一台圆二色光谱仪。这一设备将加强若干领域的研究，包括：a）合成抗冻多肽溶液结构的CD光谱; B）蚯蚓血红蛋白含血红素亚单位的构象分析; c）序列差异对蛋白质折叠能量景观形状的作用; d）不对称催化; e）同位素取代寡糖的激子手性研究。 圆二色谱是现代分析化学中一种非常有用的工具。 它提供了一个非常可靠和灵敏的方法来指定绝对分子构型。 这些研究的结果将对生物化学和其他领域产生重大影响。

With support from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at the University of South Alabama will acquire a Circular Dichroism Spectrometer. This equipment will enhance research in a number of areas including a) CD spectroscopy of the solution structure of synthetic antifreeze polypeptides; b) conformational analysis of the heme-containing subunits of lumbricus hemoglobin; c) the role of sequence differences on the shape of the protein folding energy landscape; d) asymmetric catalysis; and e) exciton chirality investigations of isotopically substituted oligosaccharides. Circular dichroism spectroscopy is an extremely useful tool in modern analytical chemistry. It provides a very reliable and sensitive method for assigning absolute molecular configurations. The results from these studies will have a strong impact in biochemistry and other areas.