CAREER: A Novel Liquid Crystal System for Capillary Electrophoresis

丽莎教授A.肯特州立大学的Holland由分析和表面化学CAREER计划资助，研究磷脂双胞作为电动毛细管色谱法的固定化分配介质。 这项工作涉及的表征的bicelle媒体详细作为一个功能的温度，混合胶束的比例，浓度和组合物。 然后将优化该材料的筛分能力，以分离多肽、蛋白质和DNA。 将利用基于生物素-抗生物素蛋白化学的双胞溶液掺入受体系统的能力。 这项工作的教育部分侧重于利用远程学习在哈斯克尔印第安民族大学发起一个研究方案。 他们的兴趣在于筛选传统部落药物的受体亲和力。

Professor Lisa A. Holland of Kent State University is funded by the Analytical and Surface Chemistry CAREER program to study phospholipid bicelles as immobilized partitioning media for electrokinetic capillary chromotography. The work involves the characterization of the bicelle media in detail as a function of temperature, mixed micelle ratios, concentration and composition. Then the sieving capabilities of this material will be optimized for separation of polypeptides, proteins and DNA. The ability of bicelle solutions to incorporate receptor systems based on biotin-avidin chemistry will be utilized. The educational component of this work focuses on the use of distance learning to initiate a research program in separations at Haskell Indian Nations University. The interest is in screening traditional tribal medicines for receptor affinity.