CAREER: Receptor Mediated Circular Dichroism Spectroscopy

有了这个职业奖的有机和高分子化学计划支持博士巴贝克Borhan的化学系在密歇根州州立大学在东兰辛，密歇根州的工作。 本工作的目的是开发一组主体分子，包含连接的四芳基卟啉锌配合物，其可以以这样的方式与客体手性刘易斯碱（如胺）配位，即组装的圆二色性光谱指示该碱的手性。 激子耦合圆二色性（ECCD）给出了一个双符号的圆二色性光谱，它的正负只取决于相互作用发色团的电跃迁偶极矩的绝对立体化学取向。Borhan博士希望开发一种光谱报告系统，用于快速确定手性有机化合物（镜像不同的化合物，如左手和右手）是左手或右手。 这种能力可能非常重要，特别是考虑到手性化合物在制药和生物学中的重要性。 除了将参与研究的研究生外，Borhan博士还将建立一个美国化学学会附属的SEED项目，该项目将把来自经济困难家庭的高中生带到实验室进行夏季研究。

With this CAREER award the Organic and Macromolecular Chemistry Program supports the work of Dr. Babek Borhan of the Department of Chemistry at Michigan State University in East Lansing, Michigan. The purpose of the work is to develop a set of host molecules, containing linked tetraaryl porphyrin zinc complexes, which can coordinate to a guest chiral Lewis base (such as an amine) in such a way that the circular dichroism spectrum of the assembly indicates the chirality of the base. The Exciton Coupled Circular Dichroism (ECCD) involved gives a bisignate CD spectrum, which is positive or negative depending only on the absolute stereochemical orientation of the electric transition dipole moment of the interacting chromophores.Dr. Borhan hopes to develop a spectroscopic reporting system which can be used to rapidly determine whether chiral organic compounds (compounds whose mirror images are different, like left and right hands) are left or right handed. This capability could be quite important, especially in view of the importance of chiral compounds in pharmaceuticals and biology. In addition to the graduate students who will be involved in the research, Dr. Borhan will establish an American Chemical Society affiliated SEED program, which will bring high school students from financially disadvantaged families into the lab for summer research experiences.